Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds

被引：19

作者：

Luciano, Paolo ^{[1
]}

Imperatore, Concetta ^{[1
]}

Senese, Maria ^{[1
]}

Aiello, Anna ^{[1
]}

Casertano, Marcello ^{[1
]}

Guo, Yue-W. ^{[2
]}

Menne, Marialuisa ^{[1
]}

机构：

[1] Univ Napoli Federico II, Dipartimento Farm, Via D Montesano,49, I-80131 Naples, Italy

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Chong Zhi Rd 555, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 07期

关键词：

NATURAL-PRODUCTS; NMR;

D O I：

10.1021/acs.jnatprod.7b00397

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8 C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.

引用

页码：2118 / 2123

页数：6

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