Generation of two induced pluripotent stem cell lines, GZHMCi009-A and GZHMCi010-A, derived from peripheral blood mononuclear cells of two SCA3 patients with 14/74 CAG repeats of the ATXN3 mutation

被引：0
|
作者：
Yang Yinghong [1 ]
Luo Qian [1 ]
Song Bing [1 ]
Xie Yingjun [1 ]
He Wenzhi [1 ]
Chen Bangzhu [1 ]
Sun Xiaofang [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Key Lab Major Obstetr Dis Guangdong Prov, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510005, Peoples R China
来源：
STEM CELL RESEARCH | 2022年 / 61卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2022.102782
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the result of abnormal repeat amplification of CAG of the ATXN3 gene. It is one of the main types of autosomal dominant ataxia, with motor symptoms of cerebellar ataxia, mainly accompanied by non-motor symptoms, such as ocular symptoms, psychiatric symptoms, and nutritional disorders. Currently, no effective treatment is available for patients with SCA3. The construction of induced pluripotent stem cells (iPSCs) from two SCA3 patients (14/74 CAG repeats) will be an excellent tool for studying SCA3 disease mechanisms and for drug screening.
引用
收藏
页数：5
相关论文
共 29 条
  • [1] Establishment of human-induced pluripotent stem cell GZHMCi0011-A from peripheral blood mononuclear cells from a volunteer with 14/63 CAG repeats of the ATXN3 mutation
    Guan, Hongmei
    Sun, Xiaofang
    Song, Bing
    STEM CELL RESEARCH, 2023, 72
  • [2] Generation of induced pluripotent stem cell GZHMCi002-A from peripheral blood mononuclear cells with APOB mutation
    Song Bing
    Liu Nengqing
    Cheng Yi
    Lu Dian
    Chen Diyu
    Xie Yingjun
    He Lina
    Yang Yinghong
    Guan Hongmei
    Sun Xiaofang
    STEM CELL RESEARCH, 2020, 49
  • [3] Generation of induced pluripotent stem cell GZHMCi001-A and GZHMCi001-B derived from peripheral blood mononuclear cells of epileptic patients with KCNC1 mutation
    Liu Nengqing
    Lu Dian
    Xie Yingjun
    Cheng Yi
    He Lina
    Chen Diyu
    Yang Yinghong
    Song Bing
    Sun Xiaofang
    STEM CELL RESEARCH, 2020, 47
  • [4] Generation of two induced pluripotent stem cell lines from peripheral blood mononuclear cells of a patient with Wilson's disease
    Malakhova, A. A.
    Grigor'eva, E., V
    Vasilyeva, O. Yu
    Zhigalina, D., I
    Skryabin, N. A.
    Sivtcev, A. A.
    Kolesnikov, N. A.
    Bueverov, A. O.
    Lebedev, I. N.
    Bogomolov, P. O.
    Zakian, S. M.
    STEM CELL RESEARCH, 2020, 47
  • [5] Generation of induced pluripotent stem cell(iPSC)line CJUHi001-A derived peripheral blood mononuclear cells of spinocerebellar ataxia type 1(SCA1) the CAG repeat mutation in ATXN1 gene
    Jin, Yinshi
    Nan, Guangxian
    STEM CELL RESEARCH, 2023, 66
  • [6] Generation of GZKHQi001-A and GZWWTi001-A, two induced pluripotent stem cell lines derived from peripheral blood mononuclear cells of Duchenne muscular dystrophy patients
    Xie Yuhuan
    Xie Yingjun
    Xue Yanting
    Chen Yuchang
    Song Bing
    Li Shaoying
    Li Haoxian
    Xian Yexing
    Ouyang Shuming
    Xiong Zeyu
    Sun Xiaofang
    STEM CELL RESEARCH, 2018, 28 : 25 - 28
  • [7] Generation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Peripheral Blood Mononuclear Cells of Patients With Atrial Fibrillation
    Mohanty, Sanghamitra
    Zhao Shuying
    Conney, Austin
    Natale, Andrea
    Wang Hongran
    CIRCULATION, 2018, 138
  • [8] Generation of Induced Pluripotent Stem Cell-derived Cardiomyocytes From Peripheral Blood Mononuclear Cells of Patients With Atrial Fibrillation
    Mohanty, Sanghamitra
    Zhao, Shuying
    Conney, Austin
    Natale, Andrea
    Wang, Hongran
    CIRCULATION, 2017, 136
  • [9] Generation of two induced pluripotent stem cell lines from patients with unbalanced translocation (3;22)
    Ma, Yanyan
    Zhang, Haiyan
    Yang, Xiaomeng
    Li, Yue
    Guan, Jingyun
    Zhang, Kaihui
    Huang, Yan
    Pan, Guangjin
    Gai, Zhongtao
    Liu, Yi
    STEM CELL RESEARCH, 2019, 40
  • [10] Generation of two human induced pluripotent stem cell lines derived from myoblasts (MDCi014-A) and from peripheral blood mononuclear cells (MDCi014-B) from the same donor
    Metzler, Eric
    Telugu, Narasimha
    Diecke, Sebastian
    Spuler, Simone
    Escobar, Helena
    STEM CELL RESEARCH, 2020, 48
123