Cytoprotective effects of 4,6-bis(1H-pyrazol-1-yl)pyrimidine and related compounds on HCl center dot ethanol-induced gastric lesions in rats

被引：0
|
作者：
Ikeda, M [1 ]
Maruyama, K [1 ]
Nobuhara, Y [1 ]
Yamada, T [1 ]
Okabe, S [1 ]
机构：
[1] NISSIN FOOD PROD CO LTD, CENT RES INST, KUSATSU, SHIGA 525, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 03期
关键词：
4,6-bis(1H-pyrazol-1-yl)pyrimidine; bicarbonate secretion; cytoprotective effect; mepirizole; dulcerozine;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4,6-bis(1H-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl . ethanol-, ethanol-, and water immersion stress-induced gastric lesions in rats, and a very low acute toxicity. One of the major factors responsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. This compound appears to be a promising cytoprotective drug for the treatment of gastric mucosal ulcers.
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收藏
页码：549 / 551
页数：3
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