A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys

被引:4
|
作者
Minh Diem Vu [1 ]
Moser, Samuel [2 ]
Delon, Camille [2 ]
Latzko, Melanie [2 ]
Gianotti, Reto [2 ]
Lueoend, Remo [2 ]
Friang, Chloe [2 ]
Murr, Ramona [2 ]
Duerner, Lydia Jasmin [2 ]
Weinzierl, Tina [2 ]
Fauti, Tanja [2 ]
Bacac, Marina [2 ]
Ast, Oliver [2 ]
Freimoser-Grundschober, Anne [2 ]
Diaz, Tea Rodriguez [2 ]
Zielonka, Joerg [2 ]
van Puijenbroek, Erwin [2 ]
Hosse, Ralf [2 ]
Bruenker, Peter [2 ]
Moessner, Ekkehard [2 ]
Klein, Christian [2 ]
Umana, Pablo [2 ]
Strein, Klaus [1 ]
机构
[1] EngMab AG, Wilen, Switzerland
[2] Roche Innovat Ctr Zurich, Schlieren, Switzerland
关键词
D O I
10.1182/blood.V126.23.2998.2998
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [1] IBI379, a novel B cell maturation antigen/CD3 bispecific T-cell engager, displays high antitumor efficacy in preclinical models of multiple myeloma
    Fei, Keke
    Ni, Haiqing
    Zhu, Mengjia
    Kuang, Zhihui
    Wu, Min
    Wu, Zhihai
    Wang, Feifei
    Zhou, Shuaixiang
    Jing, Hua
    Wu, Weiwei
    Wu, Dongdong
    Bai, Dongmei
    Chen, Bingliang
    CANCER LETTERS, 2022, 536
  • [2] A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma
    Xiong, Mengshang
    Liu, Ruoqi
    Lei, Xiaomin
    Fan, Dongmei
    Lin, Fangzhen
    Hao, Wei
    Yuan, Xiangfei
    Yang, Yuanyuan
    Zhang, Xiaolong
    Ye, Zhou
    Lu, Yang
    Zhang, Yanjun
    Wang, Jianxiang
    Xiong, Dongsheng
    JOURNAL OF IMMUNOTHERAPY, 2022, 45 (02) : 78 - 88
  • [3] Enhanced cytotoxicity in multiple myeloma via T cells armed with bispecific T cell engager targeting B-cell maturation antigen on cancer cells and CD3 on T cells
    Supimon, Kamonlapat
    Sangsuwannukul, Thanich
    Luangwattananun, Piriya
    Yenchitsomanus, Pa-thai
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 143
  • [4] Gene therapy with B-cell maturation antigen/CD3 bispecific antibody encoding plasmid DNA for treating multiple myeloma
    Peng, Fengping
    Wang, Yuan
    Zhao, Jiliang
    Liu, Hui
    Liu, Zhaoyun
    Ding, Kai
    Zhang, Hongkai
    Fu, Rong
    BRITISH JOURNAL OF HAEMATOLOGY, 2023, 201 (03) : 417 - 421
  • [5] A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
    Hipp, S.
    Tai, Y-T
    Blanset, D.
    Deegen, P.
    Wahl, J.
    Thomas, O.
    Rattel, B.
    Adam, P. J.
    Anderson, K. C.
    Friedrich, M.
    LEUKEMIA, 2017, 31 (08) : 1743 - 1751
  • [6] A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
    S Hipp
    Y-T Tai
    D Blanset
    P Deegen
    J Wahl
    O Thomas
    B Rattel
    P J Adam
    K C Anderson
    M Friedrich
    Leukemia, 2017, 31 : 1743 - 1751
  • [7] A novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
    Urara Tomita
    Yoko Ishimoto
    Masaki Ri
    Yumi Kawase
    Yoshiyuki Hizukuri
    Chikako Maru
    Kayoko Nanai
    Ryuichi Nakamura
    Makiko Nakayama
    Keiko Oguchi-Oshima
    Hiroyuki Sumi
    Toshiaki Ohtsuka
    Shinsuke Iida
    Toshinori Agatsuma
    Scientific Reports, 14
  • [8] Bi38-3 is a novel CD38/CD3 bispecific T-cell engager with low toxicity for the treatment of multiple myeloma
    Fayon, Maxime
    Martinez-Cingolani, Carolina
    Abecassis, Audrey
    Roders, Nathalie
    Nelson, Elisabeth
    Choisy, Caroline
    Talbot, Alexis
    Bensussan, Armand
    Fermand, Jean-Paul
    Arnulf, Bertrand
    Bories, Jean-Christophe
    HAEMATOLOGICA, 2021, 106 (04) : 1193 - 1197
  • [9] Erratum: A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
    S Hipp
    Y-T Tai
    D Blanset
    P Deegen
    J Wahl
    O Thomas
    B Rattel
    P J Adam
    K C Anderson
    M Friedrich
    Leukemia, 2017, 31 : 2278 - 2278
  • [10] A novel T cell-redirecting anti-GPRC5D x CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
    Tomita, Urara
    Ishimoto, Yoko
    Ri, Masaki
    Kawase, Yumi
    Hizukuri, Yoshiyuki
    Maru, Chikako
    Nanai, Kayoko
    Nakamura, Ryuichi
    Nakayama, Makiko
    Oguchi-Oshima, Keiko
    Sumi, Hiroyuki
    Ohtsuka, Toshiaki
    Iida, Shinsuke
    Agatsuma, Toshinori
    SCIENTIFIC REPORTS, 2024, 14 (01)