Mg2+ Transporters in Digestive Cancers

被引：23

作者：

Auwercx, Julie ^{[1
]}

Rybarczyk, Pierre ^{[1
,2
]}

Kischel, Philippe ^{[1
]}

Dhennin-Duthille, Isabelle ^{[1
]}

Chatelain, Denis ^{[2
]}

Sevestre, Henri ^{[1
,2
]}

Van Seuningen, Isabelle ^{[3
]}

Ouadid-Ahidouch, Halima ^{[1
]}

Jonckheere, Nicolas ^{[3
]}

Gautier, Mathieu ^{[1
]}

机构：

[1] Univ Picardie Jules Verne, UFR Sci, UR UPJV 4667, F-80000 Amiens, France

[2] CHU Amiens Picardie, Serv Anat & Cytol Pathol, F-80000 Amiens, France

[3] Univ Lille, CHU Lille, CANTHER Canc Heterogene Plast & Resistance Therap, CNRS,INSERM,U1277,UMR9020, F-59000 Lille, France

来源：

NUTRIENTS | 2021年 / 13卷 / 01期

关键词：

magnesium transporters; digestive cancers; TCGA; overall survival; POTENTIAL MELASTATIN 7; PANCREATIC-CANCER; FUNCTIONAL-CHARACTERIZATION; COLORECTAL-CANCER; MAGNESIUM INTAKE; CELL INVASION; ION CHANNELS; PROTEIN; GROWTH; TRPM7;

D O I：

10.3390/nu13010210

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters' expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.

引用

页码：1 / 22

页数：22

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