Determination of thioguanine in pharmaceutical preparations by paper substrate room temperature phosphorimetry

被引：14
|
作者：
Dong, C [1 ]
Yuan, W
Shuang, SM
Yang, P
机构：
[1] Shanxi Univ, Inst Mol Sci, Taiyuan 030006, Peoples R China
[2] Shanxi Univ, Dept Chem, Taiyuan 030006, Peoples R China
来源：
ANALYST | 2000年 / 125卷 / 07期
关键词：
D O I：
10.1039/b001597k
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A room temperature phosphorimetric (RTP) procedure was used for the determination of 6-thioguanine (6-TG). The method is based on paper substrate room temperature phosphorimetry (PS-RTP) using indium sulfate, In-2(SO4)(3) as a heavy atom perturber. Various factors affecting the room temperature phosphorescence of 6-TG are discussed. The linear dynamic range for 6-TG is from 3.3 to 334.3 ng per spot with a detection limit of 4.6 ng per spot and a relative standard deviation (RSD) of 2.38%. The recovery of standard 6-TG added to commercial tablets is in the range 96.39-98.44%. The method is simple, rapid and sensitive and can be applied to the analysis of commercial tablets without interference.
引用
收藏
页码：1327 / 1330
页数：4
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