Selenocysteine tRNAs as central components of selenoprotein biosynthesis in eukaryotes

被引：0

作者：

Park, SI ^{[1
]}

Park, JM ^{[1
]}

Chittum, HS ^{[1
]}

Yang, ES ^{[1
]}

Carlson, BA ^{[1
]}

Lee, BJ ^{[1
]}

Hatfield, DL ^{[1
]}

机构：

[1] NCI, EXPT CARCINOGENESIS LAB, NIH, BETHESDA, MD 20892 USA

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 1997年 / 10卷 / 2-3期

关键词：

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis oi Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status oi Sec tRNAs in higher animals and further we examine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); () the effect oi selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis oi the modified bases on See tRNA in Xenopus oocytes.

引用

页码：116 / 124

页数：9

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