Adherence to the Mediterranean Diet and Risk of Coronary Heart Disease in the Spanish EPIC Cohort Study

被引：265

作者：

Buckland, Genevieve ^{[1
]}

Gonzalez, Carlos A. ^{[1
]}

Agudo, Antonio ^{[1
]}

Vilardell, Mireia ^{[1
]}

Berenguer, Antoni ^{[1
]}

Amiano, Pilar ^{[2
]}

Ardanaz, Eva ^{[3
]}

Arriola, Larraitz ^{[2
]}

Barricarte, Aurelio ^{[3
]}

Basterretxea, Mikel ^{[2
]}

Dolores Chirlaque, Maria ^{[4
]}

Cirera, Lluis ^{[4
]}

Dorronsoro, Miren ^{[2
]}

Eguees, Nerea ^{[3
]}

Maria Huerta, Jose ^{[4
]}

Larranaga, Nerea ^{[2
]}

Marin, Pilar ^{[3
]}

Martinez, Carmen ^{[5
]}

Molina, Esther ^{[5
]}

Navarro, Carmen ^{[4
]}

Ramon Quiros, Jose ^{[6
]}

Rodriguez, Laudina ^{[6
]}

Sanchez, Maria-Jose ^{[5
]}

Tormo, Maria-Jose ^{[4
]}

Moreno-Iribas, Conchi ^{[3
]}

机构：

[1] Catalan Inst Oncol, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona 08907, Spain

[2] CIBERESP, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[3] CIBERESP, Publ Hlth Inst Navarra, Pamplona, Spain

[4] CIBERESP, Dept Epidenuol, Murcia Hlth Council & Consumer Affairs, Murcia, Spain

[5] CIBERESP, Andalusian Sch Publ Hlth, Granada, Spain

[6] Publ Hlth Directorate, Asturias, Spain

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2009年 / 170卷 / 12期

关键词：

cohort studies; coronary disease; diet; Mediterranean; incidence; Mediterranean region; primary prevention; ACUTE MYOCARDIAL-INFARCTION; 10 EUROPEAN COUNTRIES; LIFE-STYLE; OLIVE OIL; CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; PRIMARY PREVENTION; PHYSICAL-ACTIVITY; CONTROLLED-TRIAL; ELDERLY-PEOPLE;

D O I：

10.1093/aje/kwp282

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

No known cohort study has investigated whether the Mediterranean diet can reduce incident coronary heart disease (CHD) events in a Mediterranean population. This study examined the relation between Mediterranean diet adherence and risk of incident CHD events in the 5 Spanish centers of the European Prospective Investigation into Cancer and Nutrition. Analysis included 41,078 participants aged 29-69 years, recruited in 1992-1996 and followed up until December 2004 (mean follow-up: 10.4 years). Confirmed incident fatal and nonfatal CHD events were analyzed according to Mediterranean diet adherence, measured by using an 18-unit relative Mediterranean diet score. A total of 609 participants (79% male) had a fatal or nonfatal confirmed acute myocardial infarction (n = 468) or unstable angina requiring revascularization (n = 141). After stratification by center and age and adjustment for recognized CHD risk factors, high compared with low relative Mediterranean diet score was associated with a significant reduction in CHD risk (hazard ratio = 0.60, 95% confidence interval: 0.47, 0.77). A 1-unit increase in relative Mediterranean diet score was associated with a 6% reduced risk of CHD (95% confidence interval: 0.91, 0.97), with similar risk reductions by sex. Mediterranean diet adherence was associated with a significantly reduced CHD risk in this Mediterranean country, supporting its role in primary prevention of CHD in healthy populations.

引用

页码：1518 / 1529

页数：12

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