Nickel-Catalyzed Decarboxylative Difluoroalkylation of ,-Unsaturated Carboxylic Acids

被引：134

作者：

Li, Gang ^{[1
]}

Wang, Tao ^{[1
]}

Fei, Fan ^{[1
]}

Su, Yi-Ming ^{[1
]}

Li, Yan ^{[1
]}

Lan, Quan ^{[1
]}

Wang, Xi-Sheng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 10期

基金：

美国国家科学基金会;

关键词：

fluoroalkylation; nickel; olefins; radicals; synthetic methods; COPPER-MEDIATED TRIFLUOROMETHYLATION; CROSS-COUPLING REACTIONS; ARYL BORONIC ACIDS; FACILE ACCESS; ARYLBORONIC ACIDS; ALKYL FLUORIDES; FLUOROALKYLATION; DIFLUOROMETHYLATION; ALKENES; FLUORINATION;

D O I：

10.1002/anie.201511321

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of nickel-catalyzed decarboxylative fluoroalkylation of ,-unsaturated carboxylic acids has been developed with commonly available fluoroalkyl halides. This novel transformation has demonstrated broad substrate scope, excellent functional-group tolerance, mild reaction conditions, and excellent stereoselectivity. Mechanistic investigations indicate that a fluoroalkyl radical is involved in the catalytic cycle.

引用

页码：3491 / 3495

页数：5

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