DPAMPP in catalytic asymmetric reactions: enantioselective synthesis of L-homophenylalanine

被引：32

作者：

Xie, YN ^{[1
]}

Lou, RL ^{[1
]}

Li, Z ^{[1
]}

Mi, AQ ^{[1
]}

Jiang, YH ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(00)00092-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

L-Homophenylalanine 1, a key intermediate of most commercially important ACE inhibitors, was prepared via catalytic asymmetric hydrogenation of (Z)-2-acetamido-4-phenylcrotonate 3a with a cationic rhodium complex of(1 R,2S)-DPAMPP, followed by acid-hydrolysis of the protecting groups in good yield with >99.9% enantioselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1487 / 1494

页数：8

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