Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

被引：38

作者：

Zhou, Xian ^{[1
]}

Zhu, Xingxing ^{[1
]}

Li, Chaofan ^{[2
]}

Li, Yanfeng ^{[1
]}

Ye, Zhenqing ^{[3
]}

Shapiro, Virginia Smith ^{[4
]}

Copland, John A., III ^{[5
]}

Hitosugi, Taro ^{[6
]}

Bernlohr, David A. ^{[7
]}

Sun, Jie ^{[2
,4
]}

Zeng, Hu ^{[1
,4
]}

机构：

[1] Mayo Clin, Div Rheumatol, Dept Med, Rochester, MN 55905 USA

[2] Mayo Clin, Div Pulm & Crit Care Med, Dept Med, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Biostat & Informat, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Immunol, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA

[6] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA

[7] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

来源：

CELL REPORTS | 2021年 / 34卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; PROTECTS MICE; B-LYMPHOCYTES; INFLUENZA; REQUIREMENT; DISRUPTION; MTORC1; DIFFERENTIATION; LIPOGENESIS; METABOLISM;

D O I：

10.1016/j.celrep.2020.108601

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

引用

页数：19

共 50 条

[1] Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity
Zhou, Xian
Zhu, Xingxing
Li, Chaofan
Shapiro, Virginia
Hitosugi, Taro
Sun, Jie
Copland, John A.
Zeng, Hu
JOURNAL OF IMMUNOLOGY, 2021, 206
[2] PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase
de Brachene, Alexandra Coomans
Dif, Nicolas
Serra, Audrey de Rocca
Bonnineau, Chloe
Velghe, Amelie I.
Larondelle, Yvan
Tyteca, Donatienne
Demoulin, Jean-Baptiste
FEBS OPEN BIO, 2017, 7 (03): : 414 - 423
[3] A polymorphism in the stearoyl-CoA desaturase gene promoter influences monounsaturated fatty acid content of Duroc x Iberian hams
Henriquez-Rodriguez, Eliana
Tor, Marc
Pena, Ramona N.
Estany, Joan
SPANISH JOURNAL OF AGRICULTURAL RESEARCH, 2015, 13 (04)
[4] A polymorphism in the stearoyl-CoA desaturase gene promoter increases monounsaturated fatty acid content in dry-cured ham
Henriquez-Rodriguez, E.
Tor, M.
Pena, R. N.
Estany, J.
MEAT SCIENCE, 2015, 106 : 38 - 43
[5] Stearoyl-CoA desaturase gene expression and fatty acid concentrations in bovine tissues
Mosley, E.
Hatch, B.
Hunt, K.
Morrison, A.
Roberts, C.
Sevier, D.
McGuire, M.
JOURNAL OF ANIMAL SCIENCE, 2007, 85 : 59 - 59
[6] Stearoyl-CoA desaturase gene expression and fatty acid concentrations in bovine tissues
Mosley, E.
Hatch, B.
Hunt, K.
Morrison, A.
Roberts, C.
Sevier, D.
McGuire, M.
JOURNAL OF DAIRY SCIENCE, 2007, 90 : 59 - 59
[7] Stearoyl-CoA desaturase gene expression and fatty acid concentrations in bovine tissues
Mosley, E.
Hatch, B.
Hunt, K.
Morrison, A.
Roberts, C.
Sevier, D.
McGuire, M.
POULTRY SCIENCE, 2007, 86 : 59 - 59
[8] Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase
Hoevik, K. E.
Spydevold, O. S.
Bremer, J.
B B A - Biomembranes, 1349 (03):
[9] Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
Ntambi, JM
JOURNAL OF LIPID RESEARCH, 1999, 40 (09) : 1549 - 1558
[10] Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase
Hovik, KE
Spydevold, OS
Bremer, J
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1997, 1349 (03): : 251 - 256

← 1 2 3 4 5 →