Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis

被引：64

作者：

Muramatsu, Wataru ^{[1
]}

Hattori, Tomohiro ^{[1
]}

Yamamoto, Hisashi ^{[1
]}

机构：

[1] Chubu Univ, Mol Catalyst Res Ctr, 1200 Matsumoto Cho, Kasugai, Aichi 4878501, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 31期

基金：

日本学术振兴会;

关键词：

AMINO-ACIDS; AMIDATION; MECHANISM; EFFICIENT; PROTEINS; KINETICS; ESTERS;

D O I：

10.1021/jacs.9b03850

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new "remote" activation of carboxyl groups under solvent-free conditions. The presented method has the following advantages: (1) the high-yielding peptide synthesis uses a tantalum catalyst for any amino acids; (2) the reaction proceeds without any racemization; (3) the new substrate-directed chemical ligation using the titanium catalyst is applicable to convergent peptide synthesis. These advantages overcome some of the unresolved problems in classical peptide synthesis.

引用

页码：12288 / 12295

页数：8

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