Genetics of global gene expression

被引：461
作者：
Rockman, Matthew V.
Kruglyak, Leonid [1 ]
机构：
[1] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
[2] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
来源：
NATURE REVIEWS GENETICS | 2006年 / 7卷 / 11期
关键词：
D O I：
10.1038/nrg1964
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.
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页码：862 / 872
页数：11
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