Sensitivity of detection of B-cell lymphoma in bone marrow by fluorescence in situ hybridization

被引：3
|
作者：
Juenger, C
Stanley, WS
机构：
[1] Genet & IVF Inst, Fairfax, VA 22031 USA
[2] Coll William & Mary, Williamsburg, VA USA
来源：
CANCER GENETICS AND CYTOGENETICS | 2002年 / 138卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(02)00569-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fluorescence in situ hybridization (FISH) was used in a retrospective study of bone marrow aspirate specimens submitted for conventional cytogenetic analysis with an indication of B-cell lymphoma. About 50% of cytogenetically normal samples, which had been identified as containing lymphoma by pathology, showed small cell populations with an IGH gene rearrangement by FISH. This study demonstrates that FISH scoring of 750 nuclei provides a 99% chance of identifying the presence of lymphoma with a 14q32 aberration when this population constitutes approximately 8% of the bone marrow. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：174 / 176
页数：3
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