1p/19q chromosome deletions in metastatic oligodendroglioma

被引:20
|
作者
Merrell, Ryan
Nabors, L. Burton
Perry, Arie
Palmer, Cheryl Ann
机构
[1] Univ Alabama, Div Neuropathol, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA
[3] Washington Univ, Div Neuropathol, St Louis, MO USA
关键词
1p; 19q; chromosome deletions; metastatic oligodendroglioma; oligodendroglial neoplasms;
D O I
10.1007/s11060-006-9179-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Extracranial metastasis of primary brain tumors is a rare phenomenon. Of the few cases reported of metastatic oligodendroglioma, only two have evaluated genetic alterations, specifically deletions of chromosomes 1p and 19q. Herein, we report two additional patients with metastatic anaplastic oligodendroglioma to bone, both followed until death. All available pathology specimens were reviewed and genetic analysis was performed in one of the cases. Although the bone metastasis was non-informative, the primary intracranial tumor revealed codeletions of the 1p and 19q chromosomal arms, commonly recognized as the genetically favorable profile of oligodendrogliomas. Both patients died of complications related to their systemic disease and did not have any radiologic evidence of intracranial progression at the time of their last MRI studies. Along with the reported literature, our data suggest that despite their generally favorable behavioral profiles, oligodendroglial tumors with 1p/19q deletions may be more prone to metastasis as they progress. Genetic analysis serves a valuable ancillary role in the diagnostic workup of such cases.
引用
收藏
页码:203 / 207
页数:5
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