Iridium-Catalyzed ortho-C-H Amidation of Benzenesulfonamides with Sulfonyl Azides

被引：13
|
作者：
Hou, Hongcen [1 ]
Zhao, Yongli [1 ]
Sheng, Shouri [1 ,2 ]
Chen, Junmin [1 ,2 ]
机构：
[1] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 18期
基金：
中国国家自然科学基金;
关键词：
sulfonamides; C-H amidation; iridium; 2-aminobenzesulfonamides; sulfonyl azides; ARYL SULFONAMIDES; OXIDATIVE SYNTHESIS; BOND AMIDATION; BENZOIC-ACIDS; ACCESS; 1,1-DIOXIDES; MILD; HETEROCYCLES; DERIVATIVES; OLEFINATION;
D O I：
10.1002/adsc.201900573
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We developed herein an iridium-catalyzed direct C-H activation/ C-N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2-aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases molecular nitrogen as the sole by-product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided.
引用
收藏
页码：4393 / 4398
页数：6
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