Setting the boundaries of chromatin domains and nuclear organization

被引：178
|
作者：
Labrador, M [1 ]
Corces, VG [1 ]
机构：
[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
来源：
CELL | 2002年 / 111卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(02)01004-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nuclear architecture of the interphase nucleus is established by laying down an intricate three-dimensional framework of higher-order chromatin structure. This arrangement is essential for the integration of complex biological processes such as DNA replication, RNA processing, and transcription. Boundary or insulator elements are emerging as key players in the establishment and maintenance of this organization.
引用
收藏
页码：151 / 154
页数：4
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