Cell proliferation and morphometric changes in the rat kidney during postnatal development

被引:53
|
作者
Márquez, MG
Cabrera, I
Serrano, DJ
Sterin-Speziale, N [1 ]
机构
[1] Univ Buenos Aires, Fac Pharm & Biochem, Dept Biol Sci Cellular Biol & Histol, RA-1113 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Pharm & Biochem, Dept Sci Biol, Lab Cellular Biol & Histol,IQUIFIB CONICET, RA-1113 Buenos Aires, DF, Argentina
来源
ANATOMY AND EMBRYOLOGY | 2002年 / 205卷 / 5-6期
关键词
kidney; postnatal development; proliferation; lectin binding;
D O I
10.1007/s00429-002-0262-9
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
We have investigated the temporal maturation of the rat kidney during the postnatal developmental period. As a result, we observed the following: an active process of cortical cell proliferation and differentiation occurs as late as day 20. The medulla is the most immature zone at birth and displays the greatest morphological changes during this period. At birth, no distinction exists between inner and outer medulla, and the outer and inner strip of the outer medulla can be distinguished as late as day 30. Remodeling of the ECM surrounding collecting ducts occurs in the medulla twice, stopping at day 11 and it occurs in the papilla three times, stopping at day 20. The increase of kidney size is temporally different for each kidney zone. The cortex and the papilla acquire the morphological appearance of the adult kidney before the medulla does. Consequently, the medulla remains at the highest degree of immaturation among the kidney zones for a relatively long postnatal period.
引用
收藏
页码:431 / 440
页数:10
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