SARS-CoV-2, Hypoxia, and Calcium Signaling: The Consequences and Therapeutic Options

被引：19
|
作者：
Danta, Chhanda Charan [1 ]
机构：
[1] Univ Hull, Ctr Atherothrombosis & Metab Dis, Hull York Med Sch, Kingston Upon Hull HU6 7RX, N Humberside, England
来源：
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2021年 / 4卷 / 01期
关键词：
SARS-CoV-2; COVID-19; hypoxia; calcium signaling; inflammation; therapeutics; CHANNELS;
D O I：
10.1021/acsptsci.0c00219
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Currently, COVID-19 has created difficulties in understanding the pathological mechanisms and therapeutic options for treatment. COVID-19 patients have shown to be hypoxic, and hypoxia causes alteration of the cell calcium dynamics, which leads to alterations in many signal transduction pathways and gene expression. Also, both viruses and hypoxia directly alter many pathological and biochemical pathways, such as inflammation, cytokine signaling, glycolysis, and calcium signaling. Therefore, understanding of these cellular events would be useful in finding therapeutic options.
引用
收藏
页码：400 / 402
页数：3
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