A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity

被引：100
|
作者：
Griffith, Darren [1 ]
Morgan, Maria P. [2 ]
Marmion, Celine J. [1 ]
机构：
[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland
[2] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin 2, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 44期
基金：
爱尔兰科学基金会;
关键词：
CRYSTAL-STRUCTURE; HYDROXAMIC ACIDS; HUMAN HDAC8; COMPLEXES; CARBOPLATIN; HYDROLYSIS; CANCER; LIGANDS;
D O I：
10.1039/b916715c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.
引用
收藏
页码：6735 / 6737
页数：3
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