Reductive methylation labeling, from quantitative to structural proteomics

被引：21

作者：

Liu, Zheyi ^{[1
]}

Zhou, Ye ^{[1
]}

Liu, Jing ^{[2
]}

Chen, Jin ^{[1
]}

Heck, Albert J. R. ^{[3
]}

Wang, Fangjun ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[3] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Bijvoet Ctr Biomol Res, Biomol Mass Spectrometry & Prote, Padualaan 8, NL-3584 CH Utrecht, Netherlands

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2019年 / 118卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Reductive methylation; Stable isotope dimethyl labeling; Mass spectrometry; Quantitative proteomics; N-termini profiling; Structural proteomics; Lysine reactivity profiling; PROTEIN N-TERMINI; FORMALDEHYDE-INDUCED MODIFICATIONS; CHEMICAL CROSS-LINKING; MASS-SPECTROMETRY; PHOSPHOPROTEOME ANALYSIS; AMINO-ACID; IDENTIFICATION; LYSINE; ENRICHMENT; THROUGHPUT;

D O I：

10.1016/j.trac.2019.07.009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Reductive methylation is a highly reactive and selective chemical labeling method and plays an important role in proteomic analysis. Various applications of reductive methylation have been developed and have substantially promoted the scope of proteomic analysis to date. Aside from a well-known method for introducing isotopes, this reaction could also be conducted under biological conditions and has little structural perturbations. In this paper, we reviewed the recent developments and applications of reductive methylation in quantitative proteomics and protein N-terminal profiling, along with the emerging applications in structural proteomics for monitoring protein structural/conformational changes under various conditions. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：771 / 778

页数：8

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