Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

被引：21

作者：

Campa, Daniele ^{[1
,2
]}

McKay, James ^{[3
]}

Sinilnikova, Olga ^{[4
]}

Huesing, Anika ^{[1
]}

Vogel, Ulla ^{[5
]}

Hansen, Rikke Dalgaard ^{[6
]}

Overvad, Kim ^{[7
]}

Witt, Petra Mariann ^{[7
]}

Clavel-Chapelon, Francoise ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[8
]}

Chajes, Veronique ^{[3
,8
]}

Rohrmann, Sabine ^{[1
]}

Chang-Claude, Jenny ^{[1
]}

Boeing, Heiner ^{[9
]}

Fisher, Eva ^{[9
]}

Trichopoulou, Antonia ^{[10
]}

Trichopoulos, Dimitrios ^{[11
]}

Palli, Domenico ^{[12
]}

Villarini, Anna ^{[13
]}

Sacerdote, Carlotta ^{[14
]}

Mattiello, Amalia ^{[15
]}

Tumino, Rosario ^{[16
]}

Peeters, Petra H. M. ^{[17
]}

van Gils, Carla H. ^{[17
]}

Bueno-de-Mesquita, H. Bas ^{[18
]}

Lund, Eiliv ^{[19
]}

Dolores Chirlaque, Maria ^{[20
]}

Sala, Nuria ^{[21
]}

Rodriguez Suarez, Laudina ^{[22
]}

Barricarte, Aurelio ^{[23
]}

Dorronsoro, Miren ^{[24
,25
]}

Sanchez, Maria-Jose ^{[26
,27
]}

Lenner, Per ^{[28
]}

Hallmans, Goeran ^{[28
]}

Tsilidis, Kostas ^{[29
]}

Bingham, Sheila ^{[30
]}

Khaw, Kay-Tee ^{[30
]}

Gallo, Valentina ^{[31
]}

Norat, Teresa ^{[31
]}

Riboli, Elio ^{[31
]}

Rinaldi, Sabina ^{[3
]}

Lenoir, Gilbert ^{[8
]}

Tavtigian, Sean V. ^{[3
]}

Canzian, Federico ^{[1
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Dept Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Univ Pisa, Pisa, Italy

[3] Int Agcy Res Canc, F-69372 Lyon, France

[4] Univ Lyon 1, Hosp Civils Lyon, Ctr Leon Berard, CNRS,UMR5201, F-69365 Lyon, France

[5] Tech Univ Denmark, Natl Food Inst, Copenhagen, Denmark

[6] Danish Canc Soc, Copenhagen, Denmark

[7] Aarhus Univ Hosp, Aalborg, Denmark

[8] Inst Gustave Roussy, Villejuif, France

[9] German Inst Human Nutr, Potsdam, Germany

[10] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[11] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[12] Canc Res & Prevent Inst ISPO, Florence, Italy

[13] IRCCS, Ist Nazl Tumori, Milan, Italy

[14] CPO Piemonte, Turin, Italy

[15] Univ Naples Federico II, Naples, Italy

[16] Azienda Osped Civile MP Arezzo, Ragusa, Italy

[17] Univ Med Ctr, Julius Ctr, Utrecht, Netherlands

[18] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[19] Univ Tromso, Inst Community Med, Tromso, Norway

[20] Murcia Hlth Council, Murcia, Spain

[21] Catalan Inst Oncol, Barcelona, Spain

[22] Consejeria Salud & Serv Sanitarios Principado Ast, Oviedo, Spain

[23] Publ Hlth Inst Navarra, Pamplona, Spain

[24] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[25] CIBERESP, San Sebastian, Spain

[26] Andalusian Sch Publ Hlth, Granada, Spain

[27] CIBERESP, Granada, Spain

[28] Umea Univ, Umea, Sweden

[29] Univ Oxford, Oxford, England

[30] Univ Cambridge, Cambridge, England

[31] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 118卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Fatty acid synthase; Carbohydrate response element-binding protein; Sterol response element-binding protein-1; Breast cancer; Susceptibility to cancer; Body-mass index; GROWTH-FACTOR-I; SINGLE-NUCLEOTIDE POLYMORPHISMS; ELEMENT-BINDING PROTEIN-1C; LINKAGE DISEQUILIBRIUM; SYNTHASE INHIBITION; INSULIN-RELEASE; PROSTATE-CANCER; BETA-CELLS; IGF-I; EXPRESSION;

D O I：

10.1007/s10549-009-0347-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

引用

页码：565 / 574

页数：10

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