NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome

被引：0

作者：

Zar, Tahira ^{[1
]}

Tschernatsch, Marlene ^{[1
]}

Hero, Barbara ^{[3
]}

Lang, Bethan ^{[5
]}

Preissner, Klaus T. ^{[2
]}

Blaes, Franz ^{[1
,4
]}

机构：

[1] Justus Liebig Univ, Dept Neurol, Giessen, Germany

[2] Justus Liebig Univ, Dept Biochem, Giessen, Germany

[3] Univ Cologne, Dept Pediat Oncol, Cologne, Germany

[4] Gummersbach Acad Teaching Hosp, Dept Neurol, Wilhelm Breckow Allee 20, D-51643 Gummersbach, Germany

[5] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 02期

关键词：

opsoclonus-myoclonus syndrome; natural killer cells; autoantibodies; neuroblastoma;

D O I：

10.1097/MPH.0000000000001953

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric opsoclonus-myoclonussyndrome (OMS) is a rare autoimmune disorder of which 50% are associated with neuroblastoma (NB). We investigated whether surface-binding autoantibodies in OMS can enhance natural killer (NK) cell-mediated cytotoxicity in these patients. OMS immunoglobulin G (IgG) bound to NB cell lines and NK cell-mediated cytotoxicity to NB cells was enhanced after preincubation with OMS-IgG, but not IgG from NB without OMS or healthy controls. Activation of NK cells by surface-binding autoantibodies may be an additional mechanism of antitumor immunity in children with NB and OMS.

引用

页码：E176 / E179

页数：4

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