Regulation of lymphoid homeostasis by interleukin-15

被引：93
|
作者：
Lodolce, JP [1 ]
Burkett, PR [1 ]
Koka, RM [1 ]
Boone, DL [1 ]
Ma, A [1 ]
机构：
[1] Univ Chicago, Ben May Inst Canc Res, Dept Med, Chicago, IL 60637 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2002年 / 13卷 / 06期
关键词：
IL-15; IL-15R alpha; bystander proliferation; lymphoid homeostasis; immunological memory;
D O I：
10.1016/S1359-6101(02)00029-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：429 / 439
页数：11
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