Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation

被引:80
|
作者
Li, Yuli [1 ,2 ]
Wang, Ruijia [1 ]
Xun, Xiaogang [1 ]
Wang, Jing [1 ]
Bao, Lisui [3 ]
Thimmappa, Ramesha [4 ]
Ding, Jun [5 ]
Jiang, Jingwei [6 ]
Zhang, Liheng [5 ]
Li, Tianqi [1 ]
Lv, Jia [1 ]
Mu, Chuang [1 ]
Hu, Xiaoli [1 ,7 ]
Zhang, Lingling [1 ,2 ]
Liu, Jing [1 ]
Li, Yuqiang [1 ]
Yao, Lijie [1 ]
Jiao, Wenqian [1 ]
Wang, Yangfan [1 ]
Lian, Shanshan [1 ]
Zhao, Zelong [6 ]
Zhan, Yaoyao [5 ]
Huang, Xiaoting [1 ]
Liao, Huan [1 ]
Wang, Jia [1 ]
Sun, Hongzhen [1 ]
Mi, Xue [1 ]
Xia, Yu [1 ]
Xing, Qiang [1 ]
Lu, Wei [1 ]
Osbourn, Anne [4 ]
Zhou, Zunchun [6 ]
Chang, Yaqing [5 ]
Bao, Zhenmin [1 ,7 ]
Wang, Shi [1 ,2 ]
机构
[1] Ocean Univ China, MOE Key Lab Marine Genet & Breeding, Qingdao 266003, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
[3] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
[4] John Innes Ctr, Dept Metab Biol, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England
[5] Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
[6] Liaoning Ocean & Fisheries Sci Res Inst, Liaoning Key Lab Marine Fishery Mol Biol, Dalian 116023, Peoples R China
[7] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
来源
CELL DISCOVERY | 2018年 / 4卷
基金
英国生物技术与生命科学研究理事会; 国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词
OXIDOSQUALENE-LANOSTEROL CYCLASE; APOSTICHOPUS-JAPONICUS; GENE-EXPRESSION; HOX GENES; ECHINODERM GENOMES; HOMEOBOX GENE; REGENERATION; TRITERPENE; EVOLUTION; INTESTINE;
D O I
10.1038/s41421-018-0030-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Echinoderms exhibit several fascinating evolutionary innovations that are rarely seen in the animal kingdom, but how these animals attained such features is not well understood. Here we report the sequencing and analysis of the genome and extensive transcriptomes of the sea cucumber Apostichopus japonicus, a species from a special echinoderm group with extraordinary potential for saponin synthesis, aestivation and organ regeneration. The sea cucumber does not possess a reorganized Hox cluster as previously assumed for all echinoderms, and the spatial expression of Hox7 and Hox11/13b potentially guides the embryo-to-larva axial transformation. Contrary to the typical production of lanosterol in animal cholesterol synthesis, the oxidosqualene cyclase of sea cucumber produces parkeol for saponin synthesis and has "plant-like" motifs suggestive of convergent evolution. The transcriptional factors Klf2 and Egr1 are identified as key regulators of aestivation, probably exerting their effects through a clock gene-controlled process. Intestinal hypometabolism during aestivation is driven by the DNA hypermethylation of various metabolic gene pathways, whereas the transcriptional network of intestine regeneration involves diverse signaling pathways, including Wnt, Hippo and FGF. Decoding the sea cucumber genome provides a new avenue for an in-depth understanding of the extraordinary features of sea cucumbers and other echinoderms.
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页数:17
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