High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients

被引：36

作者：

Liu, Chao ^{[1
,2
]}

Wang, Kai ^{[3
]}

Zhang, Min ^{[4
]}

Hu, Xiaoyu ^{[2
]}

Hu, Tian ^{[5
]}

Liu, Yumei ^{[5
]}

Hu, Qinyong ^{[1
]}

Wu, Shikai ^{[6
]}

Yue, Jinbo ^{[2
]}

机构：

[1] Wuhan Univ, Dept Oncol, Renmin Hosp, Wuhan, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan, Peoples R China

[3] Southern Med Univ, Zhujiang Hosp, Dept Crit Care Med, Guangzhou, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing, Peoples R China

[5] Wuhan Hankou Hosp, Dept Resp Med, Wuhan, Peoples R China

[6] Peking Univ First Hosp, Dept Med Oncol, Beijing, Peoples R China

来源：

NPJ PRECISION ONCOLOGY | 2021年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1038/s41698-020-00139-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.

引用

页数：7

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