Synthesis of Iron Oxide Nanostructures for Hyperthermia-Based Treatments

In our research, we synthesized Fe3O4 porous/hollow through a one-pot solvothermal process and investigated their potential in hyperthermia-based treatments. An alternative magnetic field which could be automatically adjusted to control the sample temperature at a certain value was applied to characterize heating characteristics of the Fe3O4 porous/hollow nanoparticles as well as to trigger drug release from the Fe3O4 porous/hollow nanoparticles. Our study revealed that higher applied frequency resulted in the higher heat generation and thus faster temperature growth. We also demonstrated an on-off switch of the applied magnetic field to trigger the release of drug molecules, showing a faster drug release under the on-cycle rather than under the off-cycle of the applied magnetic field.