Evaluation of adverse health risks associated with antineoplastic drug exposure in nurses at two Chinese hospitals: The effects of implementing a pharmacy intravenous admixture service

被引：28

作者：

Zhang, Xiaoxia ^{[1
]}

Zheng, Qiaowei ^{[1
]}

Lv, Yun ^{[2
]}

An, Mengna ^{[1
]}

Zhang, Yating ^{[1
]}

Wei, Youxia ^{[1
]}

Feng, Weiyi ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China

[2] Shaanxi Prov Oncol Hosp, Xian, Peoples R China

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2016年 / 59卷 / 04期

关键词：

occupational exposure; antineoplastic drugs; nurse; pharmacy intravenous admixture service; healthcare system; OCCUPATIONAL-EXPOSURE; SURFACE CONTAMINATION; WORK-ENVIRONMENT; PERSONNEL; AGENTS;

D O I：

10.1002/ajim.22553

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

ObjectiveTo determine the health risks of antineoplastic drugs (ADs) occupational exposure in nurses and to evaluate the effects of implementing a pharmacy intravenous admixture service (PIVAS) in two Chinese hospitals. MethodsThe laboratory findings were collected from annual staff physical examination data. Reproductive toxicity and clinical manifestations were self-reported via a questionnaire. ResultsHematotoxicity, organ damage, reproductive toxicity, and clinical manifestations associated with AD exposure were markedly higher in oncology nurses than unexposed nurses. Application of PIVAS led to a significant restoration of the blood cell counts and kidney function, and a reduction in adverse reproductive outcomes among oncology nurses. Pronounced symptoms related to AD exposure were alleviated as well. ConclusionOncology nurses who work with AD's experienced more adverse health outcomes than unexposed nurses. The health risks to AD were significantly alleviated by implementing a pharmacy intravenous admixture service. (c) 2016 Wiley Periodicals, Inc.

引用

页码：264 / 273

页数：10