Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population-based cohort study

被引：19

作者：

Ding, Dah-Ching ^{[1
,2
,3
]}

Sung, Fung-Chang ^{[4
,5
]}

Chen, Weishan ^{[4
]}

Wang, Jen-Hung ^{[2
,6
]}

Lin, Shinn-Zong ^{[2
,7
]}

机构：

[1] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Obstet & Gynecol, Hualien, Taiwan

[2] Tzu Chi Univ, Hualien, Taiwan

[3] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan

[4] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[5] China Med Univ Hosp, Dept Hlth Serv Adm, Taichung, Taiwan

[6] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, Hualien, Taiwan

[7] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Neurosurg, Hualien, Taiwan

来源：

BREAST JOURNAL | 2020年 / 26卷 / 03期

关键词：

breast cancer; cohort study; gastric ulcer; proton pump inhibitors; retrospective;

D O I：

10.1111/tbj.13519

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We aim to evaluate breast cancer risk relating to PPIs usage in women with peptic ulcer. From 2000 to 2013, incidence rates of breast cancer were compared between the two cohorts (with or without PPIs). Each study cohort consisted of 4838 women. The incidence density rate of breast cancer in the PPI cohort was 0.29 that in the comparison cohort (10.0 vs 31.6 per 10 000 person-years), with an adjusted HR (hazard ratio) of 0.32 (95% CI = 0.20-0.49) for the PPI cohort. In conclusion, the medication of PPIs is associated with reduced breast cancer risk for women with gastric ulcer.

引用

页码：474 / 478

页数：5

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