Delineating Spatial Heterogeneity of Tumor Mutational Burden (TMB) Counts in Pulmonary Adenocarcinoma

被引：0
|
作者：
Kazdal, D. [1 ]
Allgaeuer, M. [1 ]
Budczies, J. [1 ]
Kriegsmann, M. [1 ]
Leichsenring, J. [1 ]
Volckmar, A. [1 ]
Kirchner, M. [1 ]
Neumann, O. [1 ]
Brandt, R. [1 ]
Rempel, E. [1 ]
Tala, S. [1 ]
Harms, A. [1 ]
Ploegler, C. [1 ]
Von Winterfeld, M. [1 ]
Penzel, R. [1 ]
Schirmacher, P. [1 ]
Endris, V. [1 ]
Stenzinger, A. [1 ]
机构：
[1] Univ Hosp Heidelberg, Inst Pathol, Heidelberg, Germany
来源：
JOURNAL OF THORACIC ONCOLOGY | 2019年 / 14卷 / 10期
关键词：
tumor mutational burden (TMB); Intra tumor heterogeneity; lung adenocarcinoma;
D O I：
10.1016/j.jtho.2019.08.916
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P1.04-13
引用
收藏
页码：S444 / S444
页数：1
相关论文
共 50 条
  • [1] Spatial heterogeneity of tumor mutational burden (TMB) counts in pulmonary adenocarcinoma: Separating biological effects from technical artifacts
    Endris, Volker
    Allgaeuer, Michael
    Budczies, Jan
    Leichsenring, Jonas
    Volckmar, Anna-Lena
    Kirchner, Martina
    Neumann, Olaf
    Brandt, Regine
    Rempel, Eugen
    Ploeger, Carolin
    von Winterfeld, Moritz
    Harms, Alexander
    Kriegsmann, Mark
    Penzel, Roland
    Schirmacher, Peter
    Kazdal, Daniel
    Stenzinger, Albrecht
    CANCER RESEARCH, 2019, 79 (13)
  • [2] To be or low TMB (tumor mutational burden)
    Falk, Markus
    Tiemann, Markus
    Ficker, Joachim H.
    Brueckl, Wolfgang M.
    TRANSLATIONAL CANCER RESEARCH, 2025, 14 (02) : 667 - 669
  • [3] Evaluation of spatiotemporal heterogeneity of tumor mutational burden (TMB) in gastroesophageal adenocarcinoma (GEA) at baseline diagnosis and after chemotherapy.
    Zhou, Katherine, I
    Peterson, Bryan
    Serritella, Anthony
    Reizine, Natalie
    Wang, Yan
    Catenacci, Daniel V. T.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [4] Tumor mutational burden (TMB): Assessment of inter- and intra-tumor heterogeneity.
    Conroy, Jeffrey M.
    Pabla, Sarabjot
    Glenn, Sean T.
    Nesline, Mary
    Burgher, Blake
    Lenzo, Felicia L.
    Papanicolau-Sengos, Antonios
    Gardner, Mark
    Morrison, Carl
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (08)
  • [5] Spatial and Temporal Heterogeneity of Panel-Based Tumor Mutational Burden in Pulmonary Adenocarcinoma: Separating Biology From Technical Artifacts
    Kazdal, Daniel
    Endris, Volker
    Allgaeuer, Michael
    Kriegsmann, Mark
    Leichsenring, Jonas
    Volckmar, Anna-Lena
    Harms, Alexander
    Kirchner, Martina
    Kriegsmann, Katharina
    Neumann, Olaf
    Brandt, Regine
    Talla, Suranand B.
    Rempel, Eugen
    Ploeger, Carolin
    von Winterfeld, Moritz
    Christopoulos, Petros
    Merino, Diana M.
    Stewart, Mark
    Allen, Jeff
    Bischoff, Helge
    Meister, Michael
    Muley, Thomas
    Herth, Felix
    Penzel, Roland
    Warth, Arne
    Winter, Hauke
    Froehling, Stefan
    Peters, Solange
    Swanton, Charles
    Thomas, Michael
    Schirmacher, Peter
    Budczies, Jan
    Stenzinger, Albrecht
    JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (11) : 1935 - 1947
  • [6] Tumor purity as confounder for the determination of tumor mutational burden (TMB)
    Beck, Susanne
    Menzel, Michael
    Kazdal, Daniel
    Schirmacher, Peter
    Stenzinger, Albrecht
    Budczies, Jan
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [7] Differential impact of intratumor heterogeneity (ITH) on survival outcomes in early-stage lung squamous and adenocarcinoma based on tumor mutational burden (TMB)
    Fridland, Stanislav
    Kim, Hye Sung
    Chae, Young Kwang
    Fridland, S.
    TRANSLATIONAL LUNG CANCER RESEARCH, 2024, 13 (07)
  • [8] Determinants of high tumor mutational burden (TMB) and mutational signatures in breast cancer
    Barroso-Sousa, Romualdo
    Jain, Esha
    Kim, Dewey
    Partridge, Ann H.
    Cohen, Ofir
    Wagle, Nikhil
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [9] The comparison of tumor mutational burden (TMB) in patients of early and late stage lung adenocarcinoma in China.
    Zhang, Kai
    Fei, Shihong
    Lu, Jing
    Yang, Qifan
    Yang, Jinsong
    Zeng, Yulan
    Liu, Yuting
    Xiong, Gang
    Jiao, Xiaodong
    Tao, Ye
    Yuan, Zhen
    Gao, Wei
    Wei, Zhao
    Liu, Di
    Xu, Tongfu
    Cai, Shangli
    Li, Fu-Gen
    Cao, Rubo
    Liu, Li
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [10] Inter-test variability in tumor mutational burden (TMB) quantification and identification of TMB thresholds
    Vokes, Natalie
    Jimenez Alguilar, Elizabeth
    Umeton, Renato
    Adeni, Anika
    Sholl, Lynette
    Hellmann, Matthew
    Rizvi, Hira
    Awad, Mark
    Van Allen, Eliezer
    CANCER RESEARCH, 2019, 79 (13)
12345