An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment

被引:26
|
作者
Cassano, Nicoletta [1 ]
Mastrandrea, Valentina [1 ]
Vestita, Michelangelo [1 ]
Vena, Gino Antonio [1 ]
机构
[1] Univ Bari, Dermatol Clin 2, Dept Internal Med Immunol & Infect Dis, I-70124 Bari, Italy
关键词
delayed pressure urticaria; pathogenesis; treatment; DOUBLE-BLIND; EXPRESSION; THERAPY;
D O I
10.1111/j.1529-8019.2009.01268.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.
引用
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页码:S22 / S26
页数:5
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