New catalytic system for the synthesis of imidazo[1,2-a]pyridines by the Ugi reaction

被引：15
|
作者：
Mironov, M. A. [1 ]
Tokareva, M. L. [1 ]
Ivantsova, M. N. [1 ]
Mokrushin, V. S. [1 ]
机构：
[1] Ural State Tech Univ, Ekaterinburg 620002, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2006年 / 55卷 / 10期
关键词：
Ugi reaction; isocyanides; imidazo[1,2-a]pyridine; catalysis; combinatorial synthesis; MULTICOMPONENT REACTION;
D O I：
10.1007/s11172-006-0494-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A combination of N-hydroxysuccinimide and p-toluenesulfonic acid is proposed as an efficient catalyst for the preparation of a great variety of imidazo[1,2-a]pyridine derivatives by three-component condensation of aromatic isocyanides, aldehydes, and 2-aminopyridine. The advantages of this procedure are high yields of the target products and the absence of side reactions.
引用
收藏
页码：1835 / 1839
页数：5
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