Enantioselective addition of phenylacetylene to ketones catalyzed by chiral amino alcohols

被引：6
|
作者：
Ding Juan [1 ]
Shen Zong-Xuan
Luo Xiao-Qing
Chen Wei-Yi
Zhang Ya-Wen
机构：
[1] Suzhou Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem & Chem Engn, Suzhou 215006, Jiangsu, Peoples R China
[2] Suzhou Hlth Sch, Suzhou 215007, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2006年 / 24卷 / 10期
关键词：
chiral amino alcohol; enantioselective addition; phenylacetylene; cinchonine;
D O I：
10.1002/cjoc.200690239
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(S)-(1-Benzylpyrrolidin-2-yl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields (up to 89%) and moderate enantioselectivities (up to 77.9% ee) were achieved. Addition of Ti(OPr-i)(4) can significantly improve the enantioselectivity of the reaction.
引用
收藏
页码：1285 / 1289
页数：5
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