Durable Response in Patients With Thymic Carcinoma Treated With Pembrolizumab After Prolonged Follow-Up

被引：45
|
作者：
Giaccone, Giuseppe [1 ]
Kim, Chul [1 ]
机构：
[1] Cornell Univ, Weill Cornell Med, Washington, DC USA
来源：
JOURNAL OF THORACIC ONCOLOGY | 2021年 / 16卷 / 03期
关键词：
Thymic carcinoma; Pembrolizumab; Survival; Response;
D O I：
10.1016/j.jtho.2020.11.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Here, we present an update of a phase 2 study of pembrolizumab in patients with advanced thymic carcinoma who failed previous therapies. Duration of response was approximately 3 years, and median survival was in excess of 2 years with a 5-year survival rate of 18%. The higher than expected incidence of severe autoimmune disorders (15%) did not substantially increase with a longer follow-up. Pembrolizumab induces durable responses in patients with thymic carcinoma. Careful selection of patients and monitoring of toxicities are warranted. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：483 / 485
页数：3
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