Studies on controlled release granule applied into seedling box (Part.3): Design and drug release properties of time-controlled release granule containing metominostrobin

A novel controlled drug release system on agrochemicals, time-controlled release granule (TCRG), which is characterized as an active ingredient release with a lag time, has been developed. This TCRG has a five-layered structure composed of core, active ingredient, swelling agent and two water-insoluble polymer membranes. The release profile of TCRG showed that lag time and release rate were optionally controlled by the coated amount of a water-insoluble polymer membrane, polyvinylidene chloride (PVC) and/or by the amount of a swelling agent, acrylate starch.