Drug Sensing Protein Crystals Doped with Luminescent Lanthanide Complexes

被引：12

作者：

Sun, Guotao ^{[1
]}

Tang, Jianguo ^{[1
]}

Snow, Christopher D. ^{[2
]}

Li, Zhenhua ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Yao ^{[1
]}

Belfior, Laurence A. ^{[2
]}

机构：

[1] Qingdao Univ, Coll Mat Sci & Engn, Natl Base Int Sci & Technol Cooperat, Inst Hybrid Mat,Natl Ctr Int Joint Res Hybrid Mat, Qingdao 266071, Shandong, Peoples R China

[2] Colorado State Univ, Dept Chem & Biol Engn, Ft Collins, CO 80523 USA

来源：

CRYSTAL GROWTH & DESIGN | 2019年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

LYSOZYME; GROWTH; OXIDE; EU;

D O I：

10.1021/acs.cgd.9b00642

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hen egg white lysozyme (HEWL) crystals are a model system for protein crystallization due to economical production and facile crystal growth. Here we grew small, rod-like HEWL crystals and proceeded with stepwise synthesis to dope the protein crystals with luminescent lanthanide complexes [(Eu(TTA)(3)phen] (TTA = 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato, phen = 1,10-phenanthroline). Several compounds (coumarin, tinidazole, and acridine orange) were observed to quench the lanthanide complexes in solution or embedded within crystals. Coumarin is a precursor for anticoagulant drugs and tinidazole is used to combat bacterial or protozoan infections. In contrast, acridine orange is a widely used, versatile fluorescent dye used to stain acidic vacuoles, RNA, and DNA in living cells. These results suggest that protein crystals may provide a feasible matrix for entrapping luminescent species with practical biosensing applications.

引用

页码：5658 / 5664

页数：7

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