A facile, microwave-assisted, palladium-catalyzed arylation of acetone

被引：19
|
作者：
Chobanian, Harry R. [1 ]
Liu, Ping [1 ]
Chioda, Marc D. [1 ]
Guo, Yan [1 ]
Lin, Linus S. [1 ]
机构：
[1] Merck & Co Inc, Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 07期
关键词：
D O I：
10.1016/j.tetlet.2006.12.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report an expedient method for the heteroarylation of acetone tinder tin-free conditions. The coupling is performed using the commercially available enol silane of acetone (2-trimethylsilyloxypropene) and a corresponding ary, bromide, chloride or triflate under microwave-assisted conditions, with tris(dibenzylideneacetonc)dipalladium (Pd-2(dba)(3)) or palladium acetate (Pd(OAc)(2)) and 2-(2',6'-dimethoxybiphenyl)dicyclohexylphosphine (S-Phos) as the catalyst system. Published by Elsevier Ltd.
引用
收藏
页码：1213 / 1216
页数：4
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