The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment

被引：2

作者：

Abi-Gerges, Najah ^{[1
]}

McMahon, Carrie ^{[2
]}

Vargas, Hugo ^{[3
]}

Sager, Philip ^{[4
]}

Chui, Ray ^{[3
]}

Stevens, Dale ^{[5
]}

Davila, Jonathan ^{[6
]}

Schaub, Johanna R. ^{[7
]}

Wu, Joseph C. ^{[8
]}

del Rio, Carlos ^{[9
]}

Mathes, Chris ^{[1
]}

Miller, Paul E. ^{[1
]}

Burns-Naas, Leigh Ann ^{[2
]}

Ghetti, Andre ^{[1
]}

机构：

[1] AnaBios Corp, San Diego, CA 92109 USA

[2] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA

[3] Amgen Inc, Thousand Oaks, CA 92320 USA

[4] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[5] Genentech Inc, San Francisco, CA 94080 USA

[6] NeuCyte Labs, Sunnyvale, CA 94089 USA

[7] Pliant Therapeut Inc, San Francisco, CA 94080 USA

[8] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[9] MyoKardia Inc, San Francisco, CA 94080 USA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 2019年 / 98卷

关键词：

Drug discovery; Predictivity; Safety pharmacology; Translational science; CELL-DERIVED CARDIOMYOCYTES; PREDICTIVE-VALUE; RISK-ASSESSMENT; HEART-FAILURE; QT; MODEL; CARDIOTOXICITY; RESPONSES; PARADIGM; BLOCK;

D O I：

10.1016/j.vascn.2019.106582

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Safety Pharmacology Society (SPS) held a West Coast Regional Meeting in Foster City, CA on November 14, 2018 at the Gilead Sciences Inc. site. The meeting was attended by scientists from the pharmaceutical and biotechnology industry, contract research organizations (CROs) and academia. A variety of scientific topics were presented by speakers, covering a broad variety of topics in the fields of safety risk assessment; from pro-arrhythmia and contractility risk evaluation, to models of heart failure and seizure in-a-dish; and discovery sciences; from stem cells and precision medicine, to models of inherited cardiomyopathy and precision cut tissue slices. The present review summarizes the highlights of the presentations and provides an overview of the high level of innovation currently underlying many frontiers in safety pharmacology.

引用

页数：7

共 21 条

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