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Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians
被引:11
|作者:
Harsimran, Kaur
[1
]
Singh, Arora Ajinder Pal
[2
]
Guruvinder, Singh
[3
]
Sharda, Sidhu
[1
]
Vasudha, Sambyal
[1
]
机构:
[1] Guru Nanak Dev Univ, Dept Human Genet, Amritsar 143005, Punjab, India
[2] Dr AP Singh Heart Care Ctr, Amritsar, Punjab, India
[3] Mata Kaulan Hosp, Dept Med, Amritsar, Punjab, India
来源:
DIABETES & VASCULAR DISEASE RESEARCH
|
2009年
/
6卷
/
04期
关键词:
monocyte chemoattractant protein-1 (MCP-1);
diabetes;
coronary artery disease;
North Indians;
C-REACTIVE-PROTEIN;
ALPHA;
D O I:
10.1177/1479164109346364
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis. The present study was designed to explore the relation of plasma levels of MCP-1 to disease pathology in type 2 diabetes and coronary artery disease (CAD) patients. Fasting plasma venous samples were taken from 162 subjects divided into four groups: Patients with type 2 diabetes mellitus and CAD (n=41), type 2 diabetes patients without CAD (n=50), CAD patients with no history of diabetes (n=41) and healthy controls (n=30). Coronary risk factors such as body mass index, percentage body fat, waist/hip ratio, blood pressure and physical activity were measured using standard procedures. Plasma MCP-1 was quantitatively estimated by sandwich enzyme-linked immunoabsorbent assay (ELISA). Significant differences were observed for MCP-1 levels, percent body fat, body mass index, waist/hip ratio, systolic and diastolic blood pressure amongst the groups. MCP-1 concentration was significantly correlated with diabetes duration (p<0.001), body mass index (p<0.01), waist/hip ratio (p<0.01), systolic blood pressure (p<0.01), percentage body fat (p<0.01) and physical activity level (p<0.001). MCP-1 might serve as a marker for CAD, and its association with CAD is mainly driven by traditional coronary risk factors.
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页码:288 / 290
页数:3
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