Rho GTPases and their effector proteins

被引：1635

作者：

Bishop, AL ^{[1
]}

Hall, A ^{[1
]}

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

来源：

BIOCHEMICAL JOURNAL | 2000年 / 348卷 / 02期

关键词：

actin reorganization; autoinhibition; CRIB motif; HR1; motif;

D O I：

10.1042/0264-6021:3480241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rho GTPases are molecular switches that regulate many essential cellular processes, including actin dynamics, gene transcription, cell-cycle progression and cell adhesion. About 30 potential effector proteins have been identified that interact with members of the Rho family, but it is still unclear which of these are responsible for the diverse biological effects of Rho GTPases. This review will discuss how Rho GTPases physically interact with, and regulate the activity of, multiple effector proteins and how specific effector proteins contribute to cellular responses. To date most progress has been made in the cytoskeleton held, and several biochemical links have now been established between GTPases ana the assembly of filamentous actin. The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this held.

引用

页码：241 / 255

页数：15

共 227 条

[1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].