Synthesis of 4-methoxybenzaldehyde oxime in a microfluidic chip

In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip. The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate. The effect of reaction time on the yield was determined and compared with the standard batch system. The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate, less consumption of reactants and labor contaminant, which proved microfluidic chip to be a powerful tool for synthetic applications.