Novel Graphical Representation and Numerical Characterization of DNA Sequences

被引：10
|
作者：
Li, Chun [1 ,2 ]
Fei, Wenchao [1 ]
Zhao, Yan [1 ]
Yu, Xiaoqing [3 ]
机构：
[1] Bohai Univ, Dept Math, Jinzhou 121013, Peoples R China
[2] Bohai Univ, Food Sci Res Inst, Jinzhou 121013, Peoples R China
[3] Shanghai Inst Technol, Dept Appl Math, Shanghai 201418, Peoples R China
来源：
APPLIED SCIENCES-BASEL | 2016年 / 6卷 / 03期
基金：
中国国家自然科学基金;
关键词：
numerical characterization; graphical representation; cell-based vector; phylogenetic analysis; 2-combination; SIMILARITY ANALYSIS; CURVE; TOOL;
D O I：
10.3390/app6030063
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Modern sequencing technique has provided a wealth of data on DNA sequences, which has made the analysis and comparison of sequences a very important but difficult task. In this paper, by regarding the dinucleotide as a 2-combination of the multiset [GRAPHICS] , a novel 3-D graphical representation of a DNA sequence is proposed, and its projections on planes (x,y), (y,z) and (x,z) are also discussed. In addition, based on the idea of "piecewise function", a cell-based descriptor vector is constructed to numerically characterize the DNA sequence. The utility of our approach is illustrated by the examination of phylogenetic analysis on four datasets.
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页数：15
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