Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and MO(CO)6 as carbon monoxide sources

被引：56
|
作者：
Wu, XY [1 ]
Mahalingam, AK [1 ]
Wan, YQ [1 ]
Alterman, M [1 ]
机构：
[1] Uppsala Univ, BMC, Dept Organ Pharmaceut Chem, SE-75123 Uppsala, Sweden
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 24期
关键词：
phthalides; MO(CO)(6); carbon monoxide source;
D O I：
10.1016/j.tetlet.2004.04.110
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and MO(CO)(6) were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. MO(CO)(6) was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1 h reaction time. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4635 / 4638
页数：4
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