Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro

被引：50
|
作者：
Odds, FC
Bossche, HV
机构：
[1] Univ Aberdeen, Dept Mol & Cell Biol, Inst Med Sci, Aberdeen AB25 2ZD, Scotland
[2] Janssen Res Fdn, Dept Infect Dis, B-2340 Beerse, Belgium
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷 / 03期
关键词：
D O I：
10.1093/jac/45.3.371
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Microbroth dilution tests in vitro showed the same IC50 values for itraconazole and hydroxyitraconazole, within a mode a one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode +/- one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole.
引用
收藏
页码：371 / 373
页数：3
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