Homocysteine and lipids: S-Adenosyl methionine as a key intermediate

被引：144

作者：

Obeid, Rima ^{[1
]}

Herrmann, Wolfgang ^{[1
]}

机构：

[1] Univ Saarland, Univ Hosp, Dept Clin Chem & Lab Med, Cent Lab, D-66424 Homburg, Germany

来源：

FEBS LETTERS | 2009年 / 583卷 / 08期

关键词：

Homocysteine; Cholesterol; Choline; Phosphatidylcholine; Betaine; Methionine; ENDOPLASMIC-RETICULUM STRESS; CYSTATHIONINE BETA-SYNTHASE; LOW-DENSITY-LIPOPROTEIN; CHOLINE-DEFICIENT DIET; ADENOSYLHOMOCYSTEINE HYDROLASE DEFICIENCY; ALCOHOLIC LIVER-DISEASE; A-I EXPRESSION; PLASMA HOMOCYSTEINE; PHOSPHATIDYLCHOLINE SYNTHESIS; PHOSPHATIDYLETHANOLAMINE METHYLATION;

D O I：

10.1016/j.febslet.2009.03.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been suggested. This link is clinically important in management of vascular risk factors especially in elderly people and patients with metabolic syndrome. Higher plasma homocysteine (Hcy) was associated with lower high-density lipoprotein (HDL)-cholesterol level. Moreover, HHCY was associated with disturbed plasma lipids or fatty liver. It seems that hypomethylation associated with HHCY is responsible for lipid accumulation in tissues. Decreased methyl group will decrease the synthesis of phosphatidylcholine, a major phospholipid required for very low-density lipoprotein ( VLDL) assembly and homeostasis. The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1215 / 1225

页数：11

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