Continuous-Flow Hydroxylation of Aryl Iodides Promoted by Copper Tubing

被引：9
|
作者：
Cyr, Patrick [1 ]
Charette, Andre B. [1 ]
机构：
[1] Univ Montreal, Dept Chem, Ctr Green Chem & Catalysis, Fac Arts & Sci,Stn Downtown, Montreal, PQ H3C 3J7, Canada
来源：
SYNLETT | 2014年 / 25卷 / 10期
基金：
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
phenols; copper; coupling; continuous flow; hydroxylation; CATALYZED HYDROXYLATION; SUBSTITUTED PHENOLS; EFFICIENT SYNTHESIS; HALIDES; SYSTEM; DERIVATIVES; CONVERSION; ETHERS; WATER; ACID;
D O I：
10.1055/s-0033-1338634
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and ligand-free synthesis of phenols from the corresponding aryl iodides in a continuous-flow system is described. The reaction is complete in only 4 to 20 minutes when heated between 150 to 165 degrees C in a reactor consisting of a commercially available copper coil. An example of trapping of the phenoxide in situ is also shown.
引用
收藏
页码：1409 / 1412
页数：4
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