Synthesis and analgesic activity of N-(N-acetyl-L-amino-acyl)-5-methoxytryptamines

被引：0

作者：

Han, DM ^{[1
]}

Wang, C ^{[1
]}

Zhao, M ^{[1
]}

Peng, SQ ^{[1
]}

机构：

[1] Beijing Med Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

来源：

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | 2000年 / 30卷 / 01期

关键词：

D O I：

10.1080/10826060008544943

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Methoxytryptamine was acylated with N-acetyl-L-amino acids to give rise the corresponding N-(N-acetyl-L-amino acyl)-5-methoxytryptamines. The analgesic activity was evaluated by the tail flick test. Among the 6 compounds, the analgesic potency of N-(N-acetyl-tryptophanyl)-5-methoxytryptamine (5e) and N-(N-acetyl-glycyl)-5-methoxytryptamine (5a) are much more potent than that of melatonin.

引用

页码：39 / 47

页数：9

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