Corneal Mineralization in Wistar Hannover Rats

被引：9

作者：

Hashimoto, Satomi ^{[1
]}

Doi, Takuya ^{[1
]}

Wako, Yumi ^{[1
]}

Sato, Junko ^{[1
]}

Wada, Sou ^{[2
]}

Tsuchitani, Minoru ^{[1
]}

机构：

[1] Mitsubishi Chem Medience Corp, Nonclin Res Ctr, Kashima Lab, Dept Pathol, Kamisu, Ibaraki 3140255, Japan

[2] Mitsubishi Chem Medience Corp, Nonclin Res Ctr, Kashima Lab, Dept Safety Assessment, Kamisu, Ibaraki 3140255, Japan

来源：

JOURNAL OF TOXICOLOGIC PATHOLOGY | 2013年 / 26卷 / 03期

关键词：

Wistar Hannover rat; Background data; Cornea; Mineralization; Keratocyte; OPACITIES; MICE;

D O I：

10.1293/tox.26.275

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan (TM): WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa's method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.

引用

页码：275 / 281

页数：7

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