Intramolecular cyclization reactions of aziridines with π-nucleophiles

被引：30

作者：

Bergmeier, SC ^{[1
]}

Katz, SJ ^{[1
]}

Huang, JF ^{[1
]}

McPherson, H ^{[1
]}

Donoghue, PJ ^{[1
]}

Reed, DD ^{[1
]}

机构：

[1] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 26期

基金：

美国国家科学基金会;

关键词：

aziridines; amines; bicyclic heterocyclic compounds;

D O I：

10.1016/j.tetlet.2004.05.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have found that aziridines will react with a variety of pi-nucleophiles in intramolecular cyclization reactions to produce nitrogen containing core structures found in a variety of bioactive molecules. These cyclizations are more general and facile than corresponding intermolecular reactions. We have examined the effects of ring size, pi-nucleophile identity and substitution on this reaction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5011 / 5014

页数：4

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