Ligand-free, copper-catalyzed, one-pot, three-component synthesis of novel 1,2,3-triazole-linked indoles in magnetized water

被引：12

作者：

Bakherad, Mohammad ^{[1
]}

Keivanloo, Ali ^{[1
]}

Bakherad, Zohreh ^{[2
,3
]}

Toozandejani, Zahra ^{[1
]}

Mahdavi, Mohamad ^{[4
]}

机构：

[1] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran

[2] MOH, Food & Drug Labs Res Ctr, Food & Drug Org, Tehran, Iran

[3] ME, Tehran, Iran

[4] Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2019年 / 66卷 / 06期

关键词：

1,2,3-Triazole; Click reaction; Indole; Magnetized water; AZIDE-ALKYNE CYCLOADDITION; 1,3-DIPOLAR CYCLOADDITION; CLICK CHEMISTRY; ALDOL REACTION; SOLID-PHASE; GREEN; DYNAMICS; DERIVATIVES; SOLVENT; DESIGN;

D O I：

10.1002/jccs.201800287

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetized water (MW) is used as a green and new solvent-promoting medium for the one-pot, three-component synthesis of novel 1,2,3-triazole-linked indoles catalyzed by copper iodide. A broad range of 2-aryl-1-(prop-2-ynyl)-1H-indole-3-carbaldehydes were reacted with alkyl halides and sodium azide via copper-catalyzed azide-alkyne cycloaddition reactions in MW in the absence of any ligand. This method offers the advantages of short reaction times, green procedure, low cost, simple work-up, quantitative reaction yields, and no need for any organic solvent.

引用

页码：674 / 682

页数：9

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